Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are phospholipids that normally reside in the inner leaflet of the red blood cell membrane. Their presence on the outer membrane, which is cell-age dependent, contributes to hemolysis, clotting and immune activation. In patients with sickle cell disease (SCD), studies suggest the presence of PS and PE on the surface of RBCs may lead to…